Chapter 3: Modeling the functioning of YtvA in the general stress response in Bacillus subtilis
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Modeling the functioning of YtvA in the general stress response in Bacillus subtilis.
The blue-light photoreceptor YtvA activates the general stress response (GSR) of Bacillus subtilis by activating a large protein complex (the stressosome). We have constructed a model for the YtvA's photocycle, and derived an equation for the fraction of YtvA in the light-induced signaling state at a given light intensity. The model was verified experimentally in vitro on wild type YtvA and on ...
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Here we present evidence for a physiologically relevant light response mediated by the LOV domaincontaining protein YtvA in the soil bacterium Bacillus subtilis. The loss and overproduction of YtvA abolish and enhance, respectively, the increase in -controlled ctc promoter activity at moderate light intensities. These effects were absent in the dark and in red light but present under blue-light...
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The general stress response of Bacillus subtilis can be activated by a wide range of signals, including low intensities of visible light. It is regulated by a dedicated σ factor via a complex signal transduction pathway that makes use of stressosomes: hetero-oligomeric complexes that include one or more of the RsbR proteins (RsbRA, RsbRB, RsbRC, and RsbRD). The response to blue light is mediate...
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Bacillus subtilis has found to respond the signals of environmental and metabolic stress by inducing over 40 general stress genes which are under the control of the sigma B transcription factor. Sigma B is an alternative sigma-factor in Bacillus subtilis. It mediates the response of the cell to a variety of physical insults. General stress response of Bacillus subtilis is regulated directly by ...
متن کاملChapter 4: In vivo localization of RsbRA and YtvA—regulators of the environmental branch of the general stress response of Bacillus subtilis
Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of ...
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